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Status Epilepticus

Resus council guideline 2021.

Definition (convulsive) – seizure lasting more than 5 minutes. Used to be 30 minutes! Unlikely to terminate spontaneously after 5 minutes. Evidence that the longer it lasts, the hard it is to treat.

Use existing seizure management plan, if there is one!

Buccal midazolam (0.3-0.5mg/kg depending on age) and IM/IO lorazepam 0.1mg/kg – max 2 doses of benzo’s, including any home/prehospital doses.

If no response to first dose after 5 minutes, go for IV lorazepam and prepare next step.

2nd line should then be within 15 minutes of start of seizure – Levetiracetam, phenytoin, phenobarb.

Phenytoin needs to go slowly (over 20 mins – risk of brady/asystole) cf levetiracetam (over 5 mins). Call anaesthetist.

After 5 mins, either try alternative or go for intubation and deep sedation: RSI with thiopental, or propofol +/- rocuronium. Ketamine and midaz given as alternatives as no evidence for 3rd line agent!

Meanwhile – check glucose, sodium, calcium/Mg (if sepsis). Temperature control.

Beware CNS haemorrhage (trauma?), raised intracranial pressure, meningitis, encephalitis.

[no rectal medicines mentioned but paraldehyde worked pretty well back in the day]

Sleep-related hypermotor epilepsy

Onset around age 9.

Can be just waking up, possibly confused, but multiple times a night.

Easier to diagnose if more dramatic twisting, grimacing, thrusting movements, posturing. Can be wandering like parasomnia, can be vocalisations (screaming, moaning, crying).

Can be aware during seizure. Can be sensation of unable to catch breath.

Usually around 30 secs.

Often inherited (prev called autosomal dominant frontal lobe epilepsy). Not always frontal!

Probably needs video EEG.

See also Panayiotopoulos (occipital lobe) epilepsy.

Mast cell activation syndrome

Recurrent mast cell degranulation causing episodes of hives, diarrhoea, swelling, dizziness, even anaphylaxis.

Thought to be due to clonal expansion of abnormal mast cells, not requiring usual triggers.

Diagnosis is on basis of rise in tryptase levels during an episode from base line. If base line tryptase is normal, then likely mastocytosis. Urine mast cell products eg leukotriene, prostaglandin? Look for KIT D816V on flow cytometry. Bone marrow aspiration?

Scoring systems available.

Treatment is predictably:

  • Antihistamines, preferably non sedating. Some people however benefit from the additional sedative effect of older antihistamines eg ketotifen, hydroxyzine.
  • Adrenaline autoinjectors for anaphylaxis self management
  • Montelukast/zafirlukast has systemic anti-inflammatory action
  • Famotidine has anti-histamine action
  • Steroids for short term use
  • Omalizumab

Citrus allergy

Orange, mandarin, tangerine all varieties of orange. Seeds probably rich in allergens but less likely to be eaten (chewing probably also required for reaction)!

Various allergens identified, including profilin (so oral allergy syndrome) and LTP (more in Mediterranean, cross reacts with Pru p3, not surprisingly).

One letter briefly touches on citrus cross reactivity – some tolerate lemon and/or tangerine, some had oral symptoms with tangerine, none had tried grapefruit. So varying and not well explored…

G6PD deficiency

Glucose 6 phosphate dehydrogenase deficiency. X-linked.

Can present with prolonged jaundice in babies. Otherwise with haemolysis (causing jaundice and anaemia).

Haemolysis triggered by infections, but also drugs and chemicals. Classically sulfonamides, but most relevant are:

  • Anti-malarials (ironically)
  • Nitrofurantoin!
  • Aspirin (so Kawasaki)
  • Henna! Other dyes
  • Moth balls!

Geographical risk areas –

Liminality

Liminality in medicine is the idea that you can be between illness and wellness.

Paul Turner et al give the example of having a food allergy: people with allergies do not consider themselves fully ‘ill’ or entirely ‘well’, but something in between. They are typically “well” so long as they apply food safety skills to avoid their trigger food(s) – but a slip or mistake can lead to a reaction and potentially death from anaphylaxis.

With liminality, a young person feels set apart, or a family feels their child is different from others – this can impact on self image, social interaction, which in turn can lead to denial or other unhealthy coping strategies and adverse health outcomes.

[Sanders, Soc Sci Med 2019]

Air transmission

Aerosol and droplet transmission are no longer in fashion – to be replaced by single term “air transmission”.

Similarly, no longer a list of defined “aerosol generating procedures” – flowchart to come that looks at whether coughing is induced and whether “high speed device” used.

[First letter from new Public Services Delivery body?!]

Non traditional medicine and alternative health beliefs

Non-disclosure of use of traditional, complementary and/or alternative medicine (TCAM) is found in 20 to 77% of studies. This has been attributed to an anticipated negative or dismissive response; assumption that health care professionals lack knowledge on the subject; or the HCP not asking.

HCPs who take the time to listen attentively and respectfully are more likely to have patients disclose TCAM use.

Some cultures/religions are more likely to use TCAM, and are also more likely to suffer from heath inequalities and stigma. If seen as ‘alternative’ and contrary to mainstream medicine, discussion might be perceived by both patient and doctor as irrelevant. If perceived within a more ‘integrative’ framework, it is more likely that TCAM use will be a topic for discussion. The transition from a “traditional-alternative” to a “traditional-integrative” approach to care is being promoted by the World Health Organization’s Traditional Medicine Strategy (2014–2023).

Tangkiatkumjai et al. suggested that TCAM use can be accompanied by an expectation of benefit; perception of safety; and dissatisfaction with conventional medicine. Perception of safety can of course be very misguided, eg interactions between herbal products and cancer drugs.

In oncology, integrative programs focus on quality of life-related concerns, eg chemotherapy-induced peripheral neuropathy, preoperative anxiety and postoperative pain. These programs have been shown to increase patient adherence to oncology treatment regimens, within a safe and effective environment.

Patient trust in their HCP has been shown to increase when asked directly about TCAM use.

Try the LEARN (Listen, Explain, Acknowledge, Recommend, and Negotiate) model, proposed by Berlin and Fowkes.

Non-judgmental approach essential – stereotypes, prejudices, and misconceptions may compromise the therapeutic relationship.

Other family/community voices that can be included?

“What are your goals of treatment with TCAM? Is your primarily goal to relieve your symptoms and improve your quality of life? Or is it to “fight” or cure the disease, prolong life, “strengthen” your immune system, or another goal?”

[Humility about failures/faults of conventional medicine!] [Ben-Arye, 2024]

Letters to GPs

2020 interview study with GPs in the Midlands –

Giving letters to patients has benefits of a sense of patient inclusion, increased patient understanding, patient autonomy, enhanced communication transparency. The letter can act as a memory-aid (for example, medication). Paper-held summary may also act as a physical record of the admission for future encounters and communications, particularly if the patient sees a team who do not have access to the letter (for example, out-of-hours GP).

But if discharge letter is no longer simple summary, but exercise in patient education. GP then has to wade through a lot of excess information.

Letter to patient can alarm patients (especially if inaccuracies), language barriers and patient low literacy lead to health inequalities. GP may be asked to explain letters to patients. Ethics of cases where the diagnosis had not been disclosed, confidentiality breaching if the letter contains third-party information or if patient loses the letter. Patient can be upset by sensitive issues (eg, obesity).

Tips therefore include:

  • Give patient choice regarding getting letter
  • Give patient an abbreviated/edited version
  • Include simple interpretations of results (“normal”, “satisfactory”)
  • Insert a patient information section

Common gripes:

  • Hidden Actions: Critical requests (e.g., ordering blood tests or prescribing new drugs) are often buried in paragraphs rather than clearly itemized.
  • Missing Information: Letters frequently omit the specific rationale for medication changes or leave out essential physical measurements or mental health assessments.
  • Jargon and Acronyms: Traditional letters are often written with heavy medical terminology. This confuses patients who then book GP appointments just to have the letter explained.
  • Delays: Administrative backlogs and IT glitches often mean letters arrive too late to safely guide a patient’s ongoing primary care.

What GPs Actually Want:

  • A Dedicated Action Section: GPs overwhelmingly prefer structured letters that feature a bolded “GP Action” or “Please Consider” section at the very beginning or end.
  • Concise Formatting: Because GPs spend less than a minute reading most routine letters, they favor bullet points and standardized headings for diagnoses, management plans, and required investigations.
  • Direct Communication with Patients: Medical organizations like the Academy of Medical Royal Colleges heavily promote writing clinic letters directly to the patient (in plain English) while copying in the GP. This saves GPs time and boosts patient understanding

AI in portfolios

RCPCH guidance

Using AI safely, effectively and critically is a skill that all doctors need to develop!

Generative AI tools have a significant carbon footprint. 

Doctors are expected to demonstrate their ability to be a reflective practitioner by developing both written and verbal reflection skills. AI should only be considered as a supplement to writing skills and not as a substitute.  

While AI might help with creating an outline for reflection, using AI to create artificial patient encounters or to take a purely mechanistic ‘cut and paste’ approach to ePortfolio entries risks raising concerns surrounding probity.

Educational supervisors should explore reflective ePortfolio entries with their supervisee during supervision meetings and should routinely discuss reflection and encourage verbal reflection, an essential skill for trainees. [esp serious incidents].

Doctors in training should expect to have some of their ePortfolio entries explored by their educational supervisor and/or the ARCP panel. 

Feedback and self-reflection in MSF should not be generated by AI.