Used for grass (GRAZAX) and house dust mite (ACARIZAX) allergies.

But also offered for food immunotherapy.

Hugh Windom, Sarasota (Florida) 2024– 50 patients. None needed adrenaline.

Initial doses diluted 50% in glycerine saline. Liquid egg white used. With glycerin, can be stored at room temperature for 12 months. Else freeze (No change in SPT reactivity with freezing)

Peanut, sesame (flour), wheat (Vital) diluted with glycerine to 30-40mg/ml.

(Initial dosing 1:1000 (cohort 1) abandoned as being excessively cautious)

So maintenance is 6mg for peanut. For milk/egg, 10/11mg.

Syringe preferred to dropper.

2 minute hold in mouth before swallowing (no evidence yet for shorter holds or spitting). Wait five to 15 minutes before eating or drinking (no evidence yet for shorter).

No rest (sloth) period required – exercise challenges all negative. Only skip dose if asthma flare or vomiting.
Annual OFC, +/- labs to assess response – baked for milk/egg (!), 10/30/100mg for year 1, 100/300mg year 2.

Skip 3-4 months with little loss of protection!

87% pass 140mg at 1 yr. In Canadian study (Soller 2024?) switched to OIT if passed 340mg (obviously)