Triad of:
- neuromuscular hyperactivity (hyper-reflexia, clonus) – can be inducible, ocular or spontaneous,
- autonomic instability (diaphoresis=sweating),
- hyperpyrexia.
Cool IV fluids, ice packs, bear hugger on cool, etc.
Benzodiazepines, PO/NG cyproheptadine.
RSI.
No role for antipyretics! No evidence for dantrolene. Avoid suxamethonium, fentanyl, alfentanil.