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Atopy

Funny old word – means “without place” in Greek, which refers to the fact people didn’t know what was going on with these kids – not the mechanism, not a particular infection, not a specific organ or system.

Some clues from genetic mutations – JAK1 mutations are a cause of severe atopy and eosinophilia. Involved in IL-4, IL-13, and IFN signaling. Long-term ruxolitinib (kinase inhibitor) treatment of 2 children carrying the JAK1GOF (p.A634D) variant improved their growth, eosinophilia, and clinical features of allergic inflammation.

The idea of the immune system being about defence is wrong! Tolerance is everywhere! B and T regulatory cells keep everything under control.

Microbiome in atopic conditions different, and differences can precede disease.

Neonatal gut microbiome predicts sensitisation (3 groups). Main differences are bifidobacteria and enterobacteria. Differences are related to maternal diet, delivery method, feeding method, antibiotic exposure etc.  Cumulative effect.  Still apparent at age 3.

Breast milk contains 1/3 oligosaccharides that are not digestible by baby!  Designed for microbiome!? Some genetic variations. Oligosaccharide composition associated with later sensitization.

Short chain fatty acids eg butyrate associated with sensitization – yogurt! Component of soluble fibre! Affect T reg cells.

Morganella morgani produces histamine!  Higher levels in asthma, esp higher risk.

[Liam O’Mahony – Cork, prev Davos]

Karelia study – biodiverse environments eg forest and agricultural had greater diversity of skin microbiota cf urban, shore.  Inversely related to atopy, and IL10 expression. [Finland now has national programme for allergy prevention]

Raynauds etc

Raynaud’s syndrome is where digits turn cold, white and numb transiently, usually triggered by the cold but more particularly by cold, wet weather. Can be painful and disabling.

Severe with ischaemia (ulcers, atrophy) likely to be part of a broader rheumatological syndrome.

Prevention mostly. Smoking and cocaine likely to worsen. Moisturise dry skin!

Avoid injury while numb!

Differentiate from acrocyanosis (sluggish peripheral circulation, asymptomatic, common in young children), vibration white finger, perniosis (chilblains), cervical rib, subclavian steal.

Investigations are for underlying causes, namely connective tissue disorder (especially scleroderma in adults), vasculitis, malignancy. So if unusually severe and/or atypical:

  • Full blood count
  • ANA, rheumatoid factor, antiphospholipid antibodies
  • Complement levels
  • Protein electrophoresis
  • Cold agglutinins and, in children, cryoglobulins. You don’t expect distal pallor, just blueness.

Nifedipine has most evidence to support use, other calcium channel blockers could be considered. Main side effect is low blood pressure.

Some evidence for diltiazem. Other options losartan, GTN patch, fluoxetine, alpha blockers.

For severe, sildenafil and atorvastatin! No evidence for aspirin but makes sense…

Medical Professionalism

“We teach good communication skills because we accept not everyone has them. But we also need to teach professionalism… We’re happier to challenge poor clinical skills, or to point out a gap in knowledge, than to have a conversation about behaviour or attitudes.”

“We expect learners to improve and progress.  So, by implication, they’re not perfect professionals: they can make mistakes.  It gives people permission to say, “That doesn’t look professional”.”

“We need to work on accepting  constructive feedback for unprofessional behaviours… We want a positive culture, where we teach people to speak up to promote professionalism.”

[Sheona MacLeod, BMJ 2020;368:m768]

Easier to spot when people are being unprofessional than to teach professionalism!

Which makes me think the issue is conflicting values/priorities rather than not knowing what is “good medical practice”.

So dress codes become an issue when someone’s need to express their individuality or fit in with their peer group clashes with public perceptions of what a health care professional should look like.

Or someone complaining about their work place on social media is wanting to assert their independent spirit even as an employee, perhaps also their right to self expression and to attract “likes”.

And professionalism is clearly performative. We can swear all we want in our heads, but to swear out loud (in most cases) would be considered inappropriate. Which also potentially makes class an issue.

Expectations (of the public but also our peers) change over time. Consider suits, white coats, ties, scrubs. Consider also #medbikini twitter controversy – an article by men describes social media posts of women doctors in bikinis as potentially unprofessional.

Rosenthal 2011 – humanism and professionalism student module included blogging about clerkship experiences, debriefing after significant events, and discussing journal articles, fiction, and film. Main focus however was on empathy.

Scott Oliver and Kathleen Collins described differences in attitudes between medical school students which appeared to suggest a hidden curriculum. Students with more knowledge focus failed to identify potential issues of confidentiality, ethics or trust. Students who had not explored such issues struggled to know how to approach such issues even if they did recognise them.

Definition is probably best medical practice but also the duties and responsibilities of being an employee. High level morals/values (as in GMC good medical practice) are uncontroversial but also hard to then produce policies from (and which can then be defended in court when issues arise).

Clearly some personalities can be more playful, or disagreeable, which are not necessarily negative (cf engaging, whistleblowing) so perhaps more about defining the outer limits rather than homogenizing behaviour.

Surveillance capitalism; social dilemma documentary (mental health declines with higher use; disinformation campaigns; extremism encouraged by algorithms)

Social media is performative (Erving Goffman – the presentation of self (name of his book), life as theatre (metaphorically- although some say actual)). 

MedTwitter – now X of course 

Human face vs personality cult and influencers

Social media hygiene. 

Modelling in absence of “official” voices. 

Self curation of brand. Bordieu’s social capital. 

How to teach?

Learn through active reflection on work based learning (cf how artificial PBL etc are).  Think about values, how they shape communication.  Modelling of democratic values.  Appreciation of complexity of communication.

[ Alan Bleakley, Peninsula medical school – Homer as evidence of honour/shame/face directed behaviours, cf feminine, guilt directed behaviours etc]

“We teach good communication skills because we accept not everyone has them. But we also need to teach professionalism… We’re happier to challenge poor clinical skills, or to point out a gap in knowledge, than to have a conversation about behaviour or attitudes.”

“We expect learners to improve and progress.  So, by implication, they’re not perfect professionals: they can make mistakes.  It gives people permission to say, “That doesn’t look professional”.”

“We need to work on accepting  constructive feedback for unprofessional behaviours… We want a positive culture, where we teach people to speak up to promote professionalism.”

[Sheona MacLeod, BMJ 2020;368:m768]

Keratosis pilaris

Common (familial) – rough, bumpy skin on upper arms, usually asymptomatic but cosmetically not great. Follicular plugging, basically.

Can get quite inflamed in some people.

Exfoliating, moisturizing may help.

Sometimes goes with inflamed cheeks – Keratosis pilaris rubra faciei, so typical KP of the arms (often perifollicular redness), but can lead to hair loss and atrophy of eyebrows and scalp. 

Urea containing (Balneum, Hydromol Intensive, Eucerin intensive) creams or salicylic acid (in zinc oxide) paste may help. Topical steroids can be tried if very red but risky for face, given tendency to atrophy anyway.

Sesame allergy

An emerging food allergy over the last few decades in the UK.

Sometimes isolated, but 25% of peanut allergic are also sesame allergic.

Black, white, red varieties are found – in allergy terms identical.

Other co-sensitivities are pine nut (!), brazil nut and macadamia [Helen Brough, JACI 2020].

Sesame often used in bakery products, also in Far Eastern (gomashio, furikake are sprinkled over Japanese food) and Middle eastern food. Typical white seeds are obvious (and stick to everything, which makes cross contamination a big problem) but black sesame seeds found in Japanese cooking, and tahini (sesame paste, used in hummus and dressings), are not recognisably sesame seeds at all.

Sesame oil is generally unrefined, which is to say that it is likely to contain significant amounts of sesame protein and therefore trigger reactions. With many other kinds of oil, this isn’t the case because they are refined and lack proteins.

Evidence exists that ingested whole seeds can pass through digestive tract of allergic person without causing a reaction – which can confuse diagnosis and/or suggest tolerance when it isn’t. Or delayed rupture of seed case may cause delayed but severe reactions (90 mins plus after ingestion)

Some sesame allergic appear to be sensitized to oleosins, which are not water soluble so are not found in standard skin prick and IgE test solutions, potentially giving a false negative result. In 2020 study from Israel, SPT only 33% sensitive, cf 86% (although specificity also drops to 50%). So recommended that you test with both commercial solution and shop bought tahini – if never eaten/reacted, they recommend avoiding, especially if eczema and/or other food allergies.

Self-harm

Issues around confidentiality, competence and safe guarding important here.

Involvement of family members and other carers can be really useful, if the young person agrees. Should be collaborative, of course, giving them opportunities to contribute to planning. But not just about minimising self harm behaviour – empowering and supporting (during acute distress and also in recovery) vital too.

Assessment

  • “How is your mood?”
  • “Sometimes people who feel down can start to feel hopeless about the future. Has this happened to you?”
  • “Have you ever had any thoughts about life not being worth living?” [Hurting yourself different??]
  • “Have you thought about how you might do that? Have you done anything towards that plan?”
  • Risk is then on a spectrum – engaging with treatment? Loss of protective factors eg family support?
  • Discuss removing the method of self harm – with therapeutic collaboration or negotiation, to keep the person safe
  • Discuss current support network, any safety plan (see below) or coping strategies
  • Problem solve around dynamic risk factors

Refer

 Refer to mental health professionals urgently where:

  • the person’s levels of concern or distress are rising, high or sustained
  • the frequency or degree of self-harm or suicidal intent is increasing
  • the person asks for further support from mental health services
  • levels of distress in family members or carers of children, young people and adults are rising, high or sustained, despite attempts to help.

Treatment

Work collaboratively with the person, using a strengths-based approach to identify solutions to reduce their distress that leads to self-harm.

Consider developing a safety plan:

  • recognise the triggers and warning signs
  • individualised coping strategies, including problem solving any barriers to those strategies
  • social contacts and settings that can distract from suicidal thoughts or escalating crisis
  • family members or friends to provide support and/or help resolve the crisis
  • contact details for the mental health service, including out-of-hours services and emergency contact details
  • keep the environment safe by working collaboratively to remove or restrict lethal means of suicide.

Underlying depression, anxiety, learning disabilities, autism, eating disorders should all be addressed.

For children and young people with significant emotional dysregulation difficulties who have frequent episodes of self-harm, consider dialectical behaviour therapy adapted for adolescents (DBT-A).

[NICE guidance NG225][BMJ 2017]

Alcohol and drug dependency

Early adolescence appears to be a critical time for determining the long term direction of biopsychosocial development. US studies found that those who reported their first alcoholic drink before age 14 (or drug use before age 15) were 3x more likely to develop dependence.

Regular use of cannabis before age 15 seems linked to subsequent psychosis, and risk appears to be 5x higher in daily users of high strength cannabis. But longitudinal study did not find a link after controlling for confounders. Risk probably highest where genetic or other vulnerability.

Large studies in Australia and New Zealand found frequent cannabis use predicts poor educational outcomes – some evidence for poorer memory performance (for days or even weeks after use), which might explain it (controlled for socioeconomic factors).

Inconsistent moderate associations with suicide and attempted suicide.

[National institute on drug abuse 2020]

Screening

CRAFFT –

  • Have you ever ridden in a Car driven by yourself or someone else who was high or who had been using alcohol/drugs?
  • Do you ever use alcohol/drugs to Relax, feel better about yourself or fit in?
  • Do you ever use alcohol/drugs when you are Alone?
  • Do you ever Forget things you did while using alcohol/drugs?
  • Do your family/friends ever tell you that you should cut down?
  • Have you been in Trouble while using alcohol/drugs?

2 or more yes answers “suggests an important problem”.

Intervention

Brief motivational intervention almost halved frequency of alcohol bingeing among 13-17yr olds presenting to an Emergency department. But rate also reduced in control groups.

A “confiding” parent-child relationship is linked to lower substance abuse rates. Parental knowledge of the child’s whereabouts is protective, although also likely to be proxy for confiding relationship.

Sympathetic, informed, supportive counselling as good as CBT for adolescent depression and adult alcoholism. Flexibility of services is important.

FRAMES –

  • Feedback – personalised, about risk/harm
  • Responsibility – emphasis personal responsibility for change
  • Advice – give clear advice to change habits
  • Menu – offer menu of strategies
  • Empathic – and non judgmental
  • Self efficacy – aim to increase patient’s confidence to change behaviour

Medical Humanities

In education, Johanna Shapiro has done interesting work, for example including relevant poems into objective structured clinical examinations (Female, by Ingrid Hughes, about a woman facing a probable diagnosis of breast cancer; Dear Left Knee by John Davis; Back Pain, by Ingrid Hughes; Night on Call, by Dr Rita Iovino). A large proportion said they felt it increased empathy, and had a significant effect on how they might present bad news, on the ultimate treatment plan. Most felt the Night on call poem helped gain perspective. [Medical Education 2005]

In the same paper, adding some readings led students to say (in 1/3 to 2/3 of cases) that they would be more likely to take into consideration psychosocial insights, or that it increased some dimension of empathy for the patient, including helping them take the patient more seriously.

Themes written by doctors or medical students are commonly about the rewards and stresses, relationships, role models, death, the meaning of life – things not directly addressed in the curriculum.

The quality is less important that the utility to a particular audience.

[BMJ 2010]

Long COVID

Doesn’t seem to be associated with severity of initial illness.

Long COVID is less common if you are vaccinated already. In a community based study of adults aged 18 to 69 years infected with SARS-CoV-2 before vaccination against covid-19, the odds of experiencing long covid symptoms decreased by an average of 13% after a first covid-19 vaccine dose, with a further 9% decrease in the odds of long covid after a second dose. [https://doi.org/10.1136/bmj-2021-069676

If you already have long COVID, further COVID immunisations seem to be beneficial, rather than harmful:

  • In a non-controlled study of 900 social media users with long COVID, more than half experienced an improvement in symptoms after vaccination compared with 7% who reported a deterioration.19
  • A study of 44 vaccinated patients and 22 unvaccinated controls previously admitted to hospital with covid-19 in the UK, which inevitably had limited power to detect clinically relevant effects, found no evidence for vaccination being associated with worsening of long covid symptoms or quality of life.20
  • A French study of 455 self-selected participants found reduced long COVID symptom burden and double the rate of remission at 120 days in vaccinated participants compared with unvaccinated controls.

All about symptoms, excluding treatable conditions, then self management. For adults:

https://www.yourcovidrecovery.nhs.uk/