Death from COVID19 usually from cytokine storm and multi-organ failure (often resulting in secondary haemophagocytic lymphohistiocytosis).
WHO recommends dexamethasone for severe/critical COVID19 disease, on basis of REACT metanalysis.
Severe defined as any of:
- Sats <90%
- Tachypnoea (>30 in over 5s, >40 over 2 etc)
- Severe respiratory distress
Critical defined as ARDS, septic shock or anything else that would require critical care.
For high risk (including high BMI), neutralising antibodies.
Sotrovimab – for 12-16yrs, pre-hospitalisation, PCR positive and onset of symptoms within previous 5 days. Not if new oxygen requirement or weight under 40kg. 1% vs 7% placebo hospitalisation or death (85% reduction).